Understanding Our Vitamin B12 FormsUpdated 2 months ago
We offer four different forms of Vitamin B12, each with unique properties and benefits to suit different health needs.
Available B12 Forms
Hydroxocobalamin
Hydroxocobalamin is not a form normally found in the human body and is primarily produced by bacteria. The body converts it to the useable, coenzyme forms of B12: methylcobalamin and adenosylcobalamin, the only forms able to cross the blood brain barrier. Hydroxocobalamin has a unique property: it attaches itself to cyanide and is therefore used medically for smoke inhalation victims. If glutathione is low, the conversion from hydroxocobalamin will be blocked, and methylcobalamin would be the preferred form of B12.
Cyanocobalamin
Cyanocobalamin is the cheapest and most stable form of B12 with a long shelf life. It is a synthetic form not found in nature. The body must first remove the cyanide molecule, requiring an extra conversion step before it can be converted to methylcobalamin or adenosylcobalamin. Important: Individuals with Leber's hereditary optic neuropathy should not use cyanocobalamin.
Methylcobalamin
Methylcobalamin is the most natural form of B12 and needs no converting. It is already in its "ready to use" form and is a more expensive option. Methylcobalamin is the active coenzyme form necessary for biological activity and is sometimes referred to as "active B12" because it is ready to be used by the cells. However, it is the least stable form with the shortest shelf life, converting back to hydroxycobalamin if not stored correctly.
Adenosylcobalamin
Adenosylcobalamin is also an "active" B12 form, making this coenzyme immediately available for use by the body. It is required for the enzyme MCM (Methylmalonyl Coenzyme A mutase), which resides in the mitochondria and is needed to make succinyl CoA to produce energy in the citric acid cycle. In humans, adenosylcobalamin is found mainly in tissues, especially the liver, and is the primary form of B12 found in non-human animals.
Tri B12 Liquid
Our Tri B12 Liquid combines hydroxocobalamin, adenosylcobalamin, and methylcobalamin, offering balanced support for energy, nervous system, and metabolic health. This combination approach ensures you receive all three naturally occurring forms in one supplement.
Stability Information
All forms of B12 are stable when protected from light. Light exposure cleaves cyanide molecules with the production of hydroxycobalamin. The B12 forms have optimal stability at pH 4.00-4.5, even at higher temperatures. In the presence of acidic or alkaline conditions and reducing agents such as ascorbic acid, the vitamin can be destroyed.
Learn More
For detailed information about choosing the best form of Vitamin B12 for your needs, visit our comprehensive blog article: The Best Forms of Vitamin B12 in Supplements.
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